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HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha
- 1.0340698 - BFÚ 2010 RIV GB eng J - Journal Article
Štros, Michal - Muselíková Polanská, Eva - Štruncová, S. - Pospíšilová, Š.
HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.
Nucleic Acids Research. Roč. 37, č. 7 (2009), s. 2070-2086. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA AV ČR(CZ) IAA400040702
Grant - others:GA MZd(CZ) NR9293
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : HMGB * topoisomerase IIalpha * cellular expression
Subject RIV: BO - Biophysics
Impact factor: 7.479, year: 2009
We have demonstrated that HMGB1, but not a mutant of HMGB1 incapable of DNA bending, up-regulated the activity of the topo IIalpha promoter in human cells that lack functional retinoblastoma protein pRb. Our experiments suggested a mechanism of up-regulation of cellular expression of topo IIalpha by HMGB1/2 in pRb-negative cells by modulation of binding of transcription factor NF-Y to the topo IIalpha promoter.
Permanent Link: http://hdl.handle.net/11104/0183888
Number of the records: 1