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The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets
- 1.0340614 - BFÚ 2010 RIV GB eng J - Journal Article
Brázdová Jagelská, Eva - Pivoňková, Hana - Fojta, Miroslav - Brázda, Václav
The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets.
Biochemical and Biophysical Research Communications. Roč. 391, č. 3 (2010), s. 1409-1414. ISSN 0006-291X. E-ISSN 1090-2104
R&D Projects: GA ČR(CZ) GP301/07/P160; GA ČR(CZ) GP204/07/P476; GA AV ČR(CZ) IAA500040701
Grant - others:GA ČR(CZ) GA301/10/1211
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : scDNA * plasmid pBluescript SK * linear DNA
Subject RIV: BO - Biophysics
Impact factor: 2.595, year: 2010
P53 binding to DNA is strongly influenced by DNA topology. We investigated the cruciform structure formation of various inverted repeats in p53-responsive sequences from p21, RGC, mdm2 and GAAD45 promoters under negative superhelical stress and analyzed the effects of these DNA topology changes on p53-DNA binding.
Permanent Link: http://hdl.handle.net/11104/0183823
Number of the records: 1