Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water

0340611 - ÚFCH JH 2010 RIV CZ eng J - Journal Article
Gál, Miroslav - Híveš, J. - Sokolová, Romana - Hromadová, Magdaléna - Kolivoška, Viliam - Pospíšil, Lubomír
Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water.
Collection of Czechoslovak Chemical Communications. Roč. 74, 11-12 (2009), s. 1571-1581. ISSN 0010-0765
R&D Projects: GA ČR GP203/09/P502; GA ČR GA203/09/0705; GA MŠMT LC510; GA MŠMT OC 140
Institutional research plan: CEZ:AV0Z40400503
Keywords : electrochemistry * electrochemical characteristics * aromatic nitro-compounds
Subject RIV: CG - Electrochemistry
Impact factor: 0.856, year: 2009

Electrochemical transfer of the first electron to cytotoxic radiosensitizer etanidazole (ETN) and ETN radical anion formation in the alkaline buffered aqueous solution were studied by means of electrochemical impedance spectroscopy (EIS). The heterogeneous electron transfer rate constant for the first reduction of ETN (radical anion production), k(0), was calculated. The value of k(0) from EIS measurements and the previously obtained value of so-called E-7(1) potential indicate that ETN, compared with other possible chemical radiosensitizers, requires lower energy to accept the first electron during the metabolic pathway. However, the necessity of the alkaline pH may decrease the ability of ETN to act as hypoxic radiosensitizer in the human body.
Permanent Link: http://hdl.handle.net/11104/0183820