Number of the records: 1
Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution
- 1.0340197 - ÚEM 2010 RIV NL eng J - Journal Article
Rubeš, J. - Rybář, R. - Přinosilová, P. - Věžník, Z. - Chvátalová, Irena - Solanský, I. - Šrám, Radim
Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 683, 1-2 (2010), s. 9-15. ISSN 0027-5107
R&D Projects: GA AV ČR 1QS500390506
Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : Gene-environment interaction * sperm chromatin structure assay * sperm DNA damage
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 3.204, year: 2010
The impact of PAHs and VOCs on sperm quality in a group of city policemen in Prague during winter season (high exposure) compared to spring season (low exposure) were studied. Polymorphisms in metabolic genes (CYP1A1, EPHX1, GSTM1, GSTP1, GSTT1), folic acid metabolism genes (MTR, MTHFR) and DNA repair genes (XRCC1, XPD6, XPD23, hOGG1) were evaluated as potential modifiers of associations between air pollution exposure and changes in sperm quality. No significant differences were found in any standard semen parameters between the sampling periods except for vitality of sperms.
Permanent Link: http://hdl.handle.net/11104/0183490
Number of the records: 1