Handbook of the Neuroscience of Aging

0340083 - ÚEM 2010 RIV US eng M - Monography Chapter
Syková, Eva
Aging: Extracellular Space.
Handbook of the Neuroscience of Aging. New York: Academic Press, 2009 - (Hof, P.), s. 19-26. ISBN 978-0-12-374898-0
Institutional research plan: CEZ:AV0Z50390703
Keywords : Alzheimer's * Dementia * Parkinson's
Subject RIV: FH - Neurology

Aging, as well as many neurodegenerative diseases, is accompanied by serious cognitive deficits, particularly impaired learning and memory loss. Cognitive decline in old age has been linked to changes in brain anatomy, morphology, volume, and functional deficits. Nervous tissue, particularly in the hippocampus and cortex, is subject to various degenerative processes, including a decrease in the number and efficacy of synapses, neuronal loss, astrogliosis, and changes in extracellular matrix proteins. These and other changes not only affect the efficacy of signal transmission at synapses, but could also affect extrasynaptic (“volume”) transmission, mediated by the diffusion of transmitters
Permanent Link: http://hdl.handle.net/11104/0183403