Maternal diabetes alters transcriptional programs in the developing embryo

0339735 - BTÚ 2010 RIV GB eng J - Journal Article
Pavlínková, Gabriela - Salbaum, M. - Kappen, C.
Maternal diabetes alters transcriptional programs in the developing embryo.
BMC Genomics. Roč. 10, č. 274 (2009), s. 1-12. ISSN 1471-2164. E-ISSN 1471-2164
Institutional research plan: CEZ:AV0Z50520701
Keywords : Diabetic embryopathy * microarray * hypoxia
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.759, year: 2009

Maternal diabetes is a well-known risk factor for birth defects, such as heart defects and neural tube defects. The causative molecular mechanisms in the developing embryo are currently unknown, and the pathogenesis of developmental abnormalities during diabetic pregnancy is not well understood. We here report results from gene expression profiling of exposed embryos from a mouse diabetes model. In comparison to normal embryos at mid-gestation, we find significantly altered gene expression levels in diabetes-exposed embryos. Over 30% of the genes we have identified encode transcription factors and chromatin modifying proteins or components of signaling pathways that impinge on transcription. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs.
Permanent Link: http://hdl.handle.net/11104/0183175