Comparison of follicular fluid and serum levels of Inhibin A and Inhibin B with calculated indices used as predictive markers of Ovarian Hyperstimulation Syndrome in IVF patients

0339716 - BTÚ 2010 RIV US eng J - Journal Article
Moos, J. - Řežábek, K. - Filová, V. - Moosová, M. - Pavelková, J. - Pěknicová, Jana
Comparison of follicular fluid and serum levels of Inhibin A and Inhibin B with calculated indices used as predictive markers of Ovarian Hyperstimulation Syndrome in IVF patients.
Reproductive Biology and Endocrinology. Roč. 86, č. 7 (2009), s. 1-7. E-ISSN 1477-7827
Institutional research plan: CEZ:AV0Z50520701
Keywords : ovarian hyperstimulation syndrome - OHSS * inhibin A * inhibin B * follicular fluid
Subject RIV: EC - Immunology
Impact factor: 2.077, year: 2009

Ovarian Hyperstimulation Syndrome (OHSS) is a severe health complication observed in some patients undergoing hormonal stimulation during IVF. Presence of OHSS is often associated with a high count of growing follicles responding to FSH hyperstimulation. However, the number of responding follicles may not be sufficient enough to predict the onset and severity of OHSS. The aim of this study was to find whether follicular fluid (FF) and serum concentrations of Inhibin A and Inhibin B in patients undergoing IVF treatment may serve as a predictor of OHSS status independent of the growing follicles count. Serum Inhibin A and Inhibin B concentrations showed no significant difference between the severe OHSS group and the control group without OHSS. These observations demonstrated that while neither serum nor FF concentrations of Inhibin A or Inhibin B can be used as an OHSS predictor independent of the growing follicle count, calculated indices may meet the criteria.
Permanent Link: http://hdl.handle.net/11104/0183160