Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory kapacity

0339393 - FGÚ 2010 RIV GB eng J - Journal Article
Bellance, N. - Benard, G. - Furt, F. - Begueret, H. - Smolková, Katarína - Passerieux, E. - Delage, J.P. - Baste, J.M. - Moreau, P. - Rossignol, R.
Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory kapacity.
International Journal of Biochemistry and Cell Biology. Roč. 41, č. 12 (2009), s. 2566-2577. ISSN 1357-2725. E-ISSN 1878-5875
Institutional research plan: CEZ:AV0Z50110509
Keywords : tumors * bioenergetics * biogenesis
Subject RIV: ED - Physiology
Impact factor: 4.887, year: 2009

We determined bioenergetic profiles of human fibroplasts taken from lung epidermoid carcinoma and fetal lung. We also analyzed human lung tumors and their surrounding healthy tissue from our pacients with adenocarcinoma. Results demonstrate that both the lung fetal and cancer cell lines produced their ATP predominantly by glycolysis, while oxidative phosphorylation was only capable of poor ATP delivery. A consistent reduction of mitochondrial biogenesis and the subsequent alteration of respiratory capacity was also observed in lung tumors, associated with lower expression level of bcl2
Permanent Link: http://hdl.handle.net/11104/0182938