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Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors
- 1.0339074 - FGÚ 2010 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - El-Fakahany, E. E. - Doležal, Vladimír
Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.
B M C Pharmacology. Roč. 9, č. 15 (2009), s. 1-20. ISSN 1471-2210
R&D Projects: GA ČR GA305/09/0681; GA MŠMT(CZ) LC554; GA AV ČR(CZ) IAA500110703
Institutional research plan: CEZ:AV0Z50110509
Keywords : muscarinic receptors * allosteric modulation * rapacuronium
Subject RIV: ED - Physiology
Albeit rapacuronium decreases affinity of acetylcholine under equilibrium conditions it accelerates acetylcholine binding. This results in potentiation of receptor activation by acetylcholine at low concentrations of rapacuronium. These observations highlight the necessity of performing functional tests under non-equilibrium conditions that resemble physiological conditions
Permanent Link: http://hdl.handle.net/11104/0182683
Number of the records: 1