Exhaled Leukotrienes and Bronchial Responsiveness to Methacholine in Patients with Seasonal Allergic Rhinitis

0338859 - ÚI 2010 RIV US eng J - Journal Article
Čáp, P. - Malý, Marek - Pehal, F. - Pelikán, Z.
Exhaled Leukotrienes and Bronchial Responsiveness to Methacholine in Patients with Seasonal Allergic Rhinitis.
Annals of Allergy Asthma & Immunology. Roč. 102, č. 2 (2009), s. 103-109. ISSN 1081-1206. E-ISSN 1534-4436
Grant - others:GA MZd(CZ) NL7024
Institutional research plan: CEZ:AV0Z10300504
Keywords : allergic rhinitis * asthma * breath condensate * leukotrienes * gas chromatography * mass spectrometry analysis
Subject RIV: FN - Epidemiology, Contagious Diseases ; Clinical Immunology
Impact factor: 2.457, year: 2009

Aim of the study was to investigate the relationship between the postseasonal increase in the concentration of leukotriene (LT) B4 and LTE4 in exhaled breath condensate (EBC) and bronchial responsiveness to methacholine (BRM) in patients with seasonal allergic rhinitis (SAR). In 28 patients with SAR and 50 healthy study patients, the leukotrienes were measured during and after the pollen season by gas chromatography/mass spectrometry. Following seasonal and postseasonal median values were measured in patients with SAR in comparison with control patients: LTB4: 131 and 90 pg/mL vs 80 and 79 pg/mL, P < .001 and P = .03, respectively; LTE4: 122 and 86 pg/mL vs 76 and 74 pg/mL, P < .001and P = .02, respectively. Five months after the pollen season, the concentrations of LTB4 and LTE4 decreased with respect to their seasonal values (P < .001). The seasonal and postseasonal increases in LTB4 and LTE4 concentrations in EBC correlated significantly with the later increase in BRM.
Permanent Link: http://hdl.handle.net/11104/0182521