Nanotechnology for treatment of stroke and spinal cord injury

0338739 - ÚEM 2010 RIV GB eng J - Journal Article
Kubinová, Šárka - Syková, Eva
Nanotechnology for treatment of stroke and spinal cord injury.
Nanomedicine. Roč. 5, č. 1 (2010), s. 99-108. ISSN 1743-5889. E-ISSN 1748-6963
R&D Projects: GA MŠMT(CZ) LC554; GA AV ČR IAA500390902; GA AV ČR KAN201110651; GA AV ČR KAN200520804
Grant - others:GA MŠk(CZ) 1M0538; GA ČR(CZ) GA203/09/1242; EC FP6 ENINET(XE) LSHM-CT-2005-019063; GA MZd(CZ) 1A8697
Program: 1M; GA
Institutional research plan: CEZ:AV0Z50390703
Keywords : cell therapy * contrast agents * magnetic resonance
Subject RIV: FH - Neurology
Impact factor: 6.202, year: 2010

Stem cells have been shown to selectively target injured brain and spinal cord tissue and improve functional recovery. To allow cell detection, superparamagnetic iron oxide nanoparticles can be used to label transplanted cells. Magnetic resonance imaging is then a suitable method for the in vivo tracking of grafted cells in the host organism. CNS, and particularly spinal cord, injury is accompanied by tissue damage and the formation of physical and biochemical barriers that prevent axons from regenerating. One aspect of nanomedicine is the development of biologically compatible nanofiber scaffolds that mimic the structure of the extracellular matrix and can serve as a permissive bridge for axonal regeneration or as a drug delivery system. The incorporation of biologically active epitopes and/or the utilization of these scaffolds as stem cell carriers may further enhance their therapeutic efficacy.
Permanent Link: http://hdl.handle.net/11104/0005716