Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria

0338071 - FGÚ 2010 RIV CZ eng J - Journal Article
Mitašíková, M. - Lin, H. - Soukup, Tomáš - Imanaga, I. - Tribulová, N.
Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria.
[Ovlivnění exprese konexinu 43 a PKC-ε v atriích potkana diabetem a tyroidními hormony.]
Physiological Research. Roč. 58, č. 2 (2009), s. 211-217. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GA304/05/0327; GA ČR(CZ) GA304/08/0256
Grant - others:EC(XE) LSH-CT-2004-511978; VEGA(SK) 2/6064/27; APVV(SK) 51-059505
Institutional research plan: CEZ:AV0Z50110509
Keywords : diabetes * triiodothyronine * atrial fibrillation
Subject RIV: ED - Physiology
Impact factor: 1.430, year: 2009

Cx43 expression was significantly increased after the treatment with T3 and in the acute diabetes. Both in diabetes and after T3 treatment the phosphorylation ofCx43 isoforms was markedly suppressed compared to the nondiabetic and T3-untreated controls. Such a down-regulation was less pronounced in diabetic rats after the T3-treatment. The expression of atrial PKC-ε was increased in diabetic rats. This increase was suppressed after T3 administration and the expression was decreased in T3-treated non-diabetic rats. We suggest that the reduced Cx43 phosphorylation in diabetic and hyperthyroid rats can deteriorate a cell-to-cell coupling and consequently facilitate a development of atrial tachyarrhythmia in diabetic or hyperthyroid animals

Exprese konexinu 43 byla zvýšena jak u diabetu tak i po aplikaci T3, ačkoliv hladiny fosforylované izoformy byly výrazně sníženy. Snížená fosforylace může zhoršit mezibuněčnou komunikaci a tim i srdeční činnost
Permanent Link: http://hdl.handle.net/11104/0181934