Is there a declining trend in ovarian function among infertility clinic patients?

0337970 - ÚBO 2011 RIV GB eng J - Journal Article
Sobek Jr., A. - Tkadlec, Emil - Hladíková, B. - Sobek, A.
Is there a declining trend in ovarian function among infertility clinic patients?
Human Reproduction. Roč. 25, č. 1 (2010), s. 127-132. ISSN 0268-1161. E-ISSN 1460-2350
Institutional research plan: CEZ:AV0Z60930519
Keywords : ovarian function * decrease * infertility * IVF
Subject RIV: FK - Gynaecology, Childbirth
Impact factor: 4.357, year: 2010

We examine the temporal changes in ovarian function in a large sample of infertile patients from the Czech Republic over a period of 14 years. In a retrospective study, we analysed a large body of data from women, 20-40 years of age, undergoing IVF/ICSI treatment between 1995 and 2008. We defined ovarian function using five variables: basal FSH level, estradiol (E2) level on the day of HCG administration, dose of gonadotrophins used for ovarian stimulation, number of retrieved oocytes and dose of gonadotrophins per oocyte. Controlling simultaneously for temporal changes in patient age and stimulation protocol, we applied generalized additive models to describe the temporal trends. The results are indicative of a small, but detectable decrease in ovarian function over a period of 14 years, which is not causally related to the ageing population.
Permanent Link: http://hdl.handle.net/11104/0181847