The DNA-damage response in human biology and disease

0337838 - ÚMG 2010 RIV GB eng J - Journal Article
Jackson, S.P. - Bártek, Jiří
The DNA-damage response in human biology and disease.
Nature. Roč. 461, č. 7267 (2009), s. 1071-1078. ISSN 0028-0836. E-ISSN 1476-4687
Institutional research plan: CEZ:AV0Z50520514
Keywords : DNA damage response * human disease * cancer
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 34.480, year: 2009

The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.
Permanent Link: http://hdl.handle.net/11104/0181743