In vitro anti-inflammatory and anticancer activities of extracts of Acalypha alopecuroidea (Euphorbiaceae)

0337009 - ÚEB 2010 RIV GR eng J - Journal Article
Madlener, S. - Svačinová, Jana - Kitner, Miloslav - Kopecký, Jiří - Eytner, R. - Lackner, A. - Vo, T. P. N. - Frisch, R. - Grusch, M. - De Martin, R. - Doležal, Karel - Strnad, Miroslav - Krupitza, G.
In vitro anti-inflammatory and anticancer activities of extracts of Acalypha alopecuroidea (Euphorbiaceae).
International Journal of Oncology. Roč. 35, č. 4 (2009), s. 881-891. ISSN 1019-6439. E-ISSN 1791-2423
Institutional research plan: CEZ:AV0Z50380511; CEZ:AV0Z50200510
Keywords : Acalypha alopecuroidea * cancer * anti-inflammatory activity
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.447, year: 2009

More than 60% of conventional drugs are derived from natural compounds, some of the most effective pharmaceuticals originate from plants or microbes, and large numbers of potentially valuable natural substances remain to be discovered. Plants with considerable medicinal potential include members of the genus Acalypha. Notably, extracts of several species have been recently shown to have antioxidant, antimicrobial and cytotoxic effects. In the study we investigated the anti-inflammatory, anti-proliferative and proapoptotic activities of A. alopecitroidea, which is endemic in parts of Central America and is traditionally used as decoctions or as a tea. We demonstrate here that extracts of A. alopecitroidea can inhibit TNF alpha-induced E-selectin production. Furthermore, a fraction of A. alopecitroidea root extracts purified by solid phase extraction and HPLC displayed strong cell cycle inhibitory activity by down-regulating and inactivating two proto-oncogenes.
Permanent Link: http://hdl.handle.net/11104/0181105