Current and Novel Inhibitors of HIV Protease

0336551 - ÚOCHB 2011 RIV CH eng J - Journal Article
Pokorná, Jana - Machala, L. - Řezáčová, Pavlína - Konvalinka, Jan
Current and Novel Inhibitors of HIV Protease.
Viruses. Roč. 1, č. 3 (2009), s. 1209-1239. E-ISSN 1999-4915
R&D Projects: GA MŠMT 1M0508
Grant - others:GA AV ČR(CZ) IAAX00320901
Program: IA
Institutional research plan: CEZ:AV0Z40550506
Keywords : HIV protease * protease inhibitor * HAART
Subject RIV: CE - Biochemistry

This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed.
Permanent Link: http://hdl.handle.net/11104/0180760