Novel Juvenogens (Insect Hormonogenic Agents): Preparation and Biological Tests on Neobellieria bullata

0335905 - ÚEB 2010 RIV US eng J - Journal Article
Jurček, Ondřej - Wimmer, Zdeněk - Bennettová, Blanka - Moravcová, J. - Drašar, P. - Šaman, David
Novel Juvenogens (Insect Hormonogenic Agents): Preparation and Biological Tests on Neobellieria bullata.
[Nové juvenogeny (hmyzí hormonogenní prostředky): Příprava a biologické testy na Neobellieria bullata.]
Journal of Agricultural and Food Chemistry. Roč. 57, č. 22 (2009), s. 10852-10858. ISSN 0021-8561. E-ISSN 1520-5118
R&D Projects: GA MŠMT 2B06024; GA ČR GA206/08/0015
Institutional research plan: CEZ:AV0Z50380511; CEZ:AV0Z50070508; CEZ:AV0Z40550506
Keywords : Neobellieria bullata * insecticide * juvenoid
Subject RIV: CC - Organic Chemistry
Impact factor: 2.469, year: 2009

The development of new types of environmentally safe insecticides has been advantageous to replace toxic and persistent insecticides, which have adverse effects on animals and humans. Our effort in this field was aimed at the synthesis of insect juvenile hormone analogues, juvenoids, nontoxic for warm-blooded animals and fish, which can become advanced compounds in regulating many aspects in insect physiology. Structure modification of juvenoids via juvenogen derivatives (hormonogenic substances) plays an important role in controlling the juvenoid liberation rate in the insect digestive system and can also play an important role in the mode of action toward different arthropod groups, with focus on insect pest species. For that reason, juvenoids were esterified with hexadecanoic, butanoic, and 3-methylbut-2-enoic acids. A total of 12 new compounds with potential insecticidal activity were synthesized and characterized, and the results of biological screening tests.

Vývoj nových typů ekologicky bezpečných insekticidů je žádoucí, aby nahradil toxické a persistentní insekticidy, které mají nepříznivý vliv na živočichy a na člověka. Bylo připraveno celkem 12 nových sloučenin, které byly charakterizovány a použity pro testování na mouše Neobellieria bullata.
Permanent Link: http://hdl.handle.net/11104/0180251