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Morphological changes in human neural cells followign tick-borne encephalitis infection
- 1.0335287 - BC 2010 RIV GB eng J - Journal Article
Růžek, Daniel - Vancová, Marie - Tesařová, Martina - Ahantarig, A. - Kopecký, Jan - Grubhoffer, Libor
Morphological changes in human neural cells followign tick-borne encephalitis infection.
Journal of General Virology. Roč. 90, č. 7 (2009), s. 1649-1658. ISSN 0022-1317. E-ISSN 1465-2099
R&D Projects: GA ČR GA524/08/1509; GA MŠMT(CZ) LC06009
Institutional research plan: CEZ:AV0Z60220518
Keywords : tick-borne encephalitis virus * human neural cells * central nervous system
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.260, year: 2009
Tick-borne encephalitis (TBE) is one of the leading and most dangerous human viral neuroinfections in Europe and north-eastern Asia. The clinical manifestations include asymptomatic infections, fevers and debilitating encephalitis that might progress into chronic disease or fatal infection. To understand TBE pathology further in host nervous systems, three human neural cell lines, neuroblastoma, medulloblastoma and glioblastoma, were infected with TBE virus (TBEV). The susceptibility and virus-mediated cytopathic effect, including ultrastructural and apoptotic changes of the cells, were examined. The neuropathological significance of the observations is discussed.
Permanent Link: http://hdl.handle.net/11104/0179794
Number of the records: 1