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Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin
- 1.0335110 - ÚIACH 2010 RIV GB eng J - Journal Article
Kubíková, I. - Konečná, H. - Šedo, O. - Zdráhal, Z. - Řehulka, Pavel - Hříbková, H. - Řehulková, Helena - Hampl, Aleš - Chmelík, Josef - Dvořák, Petr
Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin.
Cytotherapy. Roč. 11, č. 3 (2009), s. 330-340. ISSN 1465-3249. E-ISSN 1477-2566
R&D Projects: GA MŠMT 1M0538
Institutional research plan: CEZ:AV0Z40310501; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : human embryonic stem cell * hESC * proteomic profiling
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.204, year: 2009
Microvesicles (MVs) shed from the plasma membrane of eukaryotic cells including human embryonic stem cells (hESCs) contain proteins, lipids, and RNAs and serve as mediators of cell-to-cell communication. However, they may also contain immunogenic membrane domains or infectious particles acquired from xenogenic components of the culture milieu. Therefore, MVs represent a potential risk for the clinical application of cell therapy.
Permanent Link: http://hdl.handle.net/11104/0179676
Number of the records: 1