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An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens
- 1.0334523 - MBÚ 2010 RIV US eng J - Journal Article
Juguet, M. - Lautru, S. - Francou, F.-X. - Nezbedová, Šárka - Leblond, P. - Gondry, M. - Pernodet, J. L.
An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens.
Chemistry & Biology. Roč. 16, č. 4 (2009), s. 421-431. ISSN 1074-5521
Institutional research plan: CEZ:AV0Z50200510
Keywords : ADENYLATION DOMAINS * ESCHERICHIA-COLI * FUNCTIONAL-ANALYSIS
Subject RIV: CE - Biochemistry
Impact factor: 6.523, year: 2009
The biosynthetic cluster directing the biosynthesis of the oligopyrol antibiotic congocidine was identified. For nine genes from the cluster it was possible to assign specific functions in congocidine biosynthesis, regulation or resistance. Further studies on its biosynthesis revealed that it is carried out by an iterative non-ribosomal peptide synthase that posses several original features
Permanent Link: http://hdl.handle.net/11104/0179236
Number of the records: 1