Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III beta-tubulin

0334046 - ÚMG 2010 RIV US eng J - Journal Article
Katsetos, C.D. - Dráberová, Eduarda - Legido, A. - Dumontet, C. - Dráber, Pavel
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III beta-tubulin.
Journal of Cellular Physiology. Roč. 221, č. 3 (2009), s. 505-513. ISSN 0021-9541. E-ISSN 1097-4652
R&D Projects: GA AV ČR KAN200520701
Institutional research plan: CEZ:AV0Z50520514
Keywords : Beta-II-tubulin * glioblastoma
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.586, year: 2009

This minireview focuses on microtubules and tubulin as emerging targets in potential therapy of GBM using a new class of betaIII-tubulin-targeted drugs in the light of recent developments concerning the function and potential role of this isotype in clinically aggressive tumor behavior, cancer stem cells, tumor hypoxia and chemoresistance to tubulin binding agents, principally taxanes.
Permanent Link: http://hdl.handle.net/11104/0178881