Signalling activated by the death receptors of the TNRF family

0333976 - ÚMG 2010 RIV CZ eng J - Journal Article
Anděra, Ladislav
Signalling activated by the death receptors of the TNRF family.
Biomedical Papers. Roč. 153, č. 3 (2009), s. 173-180. ISSN 1213-8118. E-ISSN 1804-7521
R&D Projects: GA MŠMT 1M0506
Grant - others:AV ČR(CZ) KAN200520703
Program: KA
Institutional research plan: CEZ:AV0Z50520514
Keywords : death receptors * apoptosis * signaling
Subject RIV: EB - Genetics ; Molecular Biology

Among the most prominent players in the field of the extracellular signals leading to cell death, preferentially through induction of apoptosis belong several receptors from so-called Death Receptors group of the Tumour Necrosis Factors Receptors (TNFR) family. Over 15 years of the research on activation and regulation of the most prominent member of this group – receptors for the ligands TRAIL, FasL and TNFa brought not only a detail (and still refining) mechanism of these receptors activation and downstream signaling, but also connected them with the ultimate apoptotic gatekeeper – mitochondria. However, in addition to the pro-death signaling, these receptors were also shown under certain circumstances to activate an opposite, pro-proliferative signaling as well as to participate in pro-inflammatory responses.
Permanent Link: http://hdl.handle.net/11104/0178826