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The central region of BRCA1 binds preferentially to supercoiled DNA
- 1.0333779 - BFÚ 2010 RIV US eng J - Journal Article
Brázda, Václav - Brázdová Jagelská, Eva - Liao, J.C.C. - Arrowsmith, Ch.H.
The central region of BRCA1 binds preferentially to supercoiled DNA.
[Centrální doména proteinu BRCA1 se váže preferenčně na superhelikální DNA.]
Journal of Biomolecular Structure & Dynamics. Roč. 27, č. 1 (2009), s. 97-103. ISSN 0739-1102
R&D Projects: GA ČR(CZ) GP301/07/P160; GA MŠMT(CZ) LC06035; GA AV ČR(CZ) IAA500040701
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : BRCA1 protein * DNA binding * protein-DNA complex
Subject RIV: BO - Biophysics
Impact factor: 1.124, year: 2009
BRCA1 is a multifunctional tumor suppressor protein with implications in regulating processes such as cell cycle, transcription, DNA repair and chromatin remodeling with preferential binding on superhelical DNA.
BRCA1 protein zastává v buňce řadu významných funkcí a preferenčně se váže na DNA.
Permanent Link: http://hdl.handle.net/11104/0178689
Number of the records: 1