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Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
- 1.0333208 - ÚCHP 2011 RIV CH eng J - Journal Article
Kuča, K. - Musilová, L. - Paleček, J. - Církva, Vladimír - Paar, M. - Musílek, K. - Hrabinová, M. - Pohanka, M. - Zdarová Karasová, J. - Jun, D.
Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon.
Molecules. Roč. 14, č. 12 (2009), s. 4915-4921. E-ISSN 1420-3049
Grant - others:MO0(CZ) FZV0000604
Institutional research plan: CEZ:AV0Z40720504
Keywords : acetylcholinesterase * reactivator * oxime
Subject RIV: CC - Organic Chemistry
Impact factor: 1.738, year: 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators—pralidoxime, obidoxime and HI-6—which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime.
Permanent Link: http://hdl.handle.net/11104/0178252
Number of the records: 1