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Hemoglobin digestion in blood-feeding ticks: mapping of multipeptidase pathway by functional proteomics

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    0333131 - ÚOCHB 2010 RIV US eng J - Journal Article
    Horn, Martin - Nussbaumerová, Martina - Šanda, Miloslav - Kovářová, Zuzana - Srba, Jindřich - Franta, Zdeněk - Sojka, Daniel - Bogyo, M. - Caffrey, C. R. - Kopáček, Petr - Mareš, Michael
    Hemoglobin digestion in blood-feeding ticks: mapping of multipeptidase pathway by functional proteomics.
    Chemistry & Biology. Roč. 16, č. 10 (2009), s. 1053-1063. ISSN 1074-5521
    R&D Projects: GA ČR GA206/06/0865; GA AV ČR IAA600960910; GA MŠMT(CZ) LC06009; GA AV ČR KJB400550516
    Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z60220518
    Keywords : peptidases * active-site probes * hemoglobinolysis * tick digestion * Ixodes ricinus
    Subject RIV: CE - Biochemistry
    Impact factor: 6.523, year: 2009

    Hemoglobin digestion is an essential process for blood-feeding parasites. We deconvoluted the hemoglobinolytic cascade in the tick Ixodes ricinus, a vector of Lyme disease and tick-borne encephalitis. A network of digestive peptidases was demonstrated through imaging with specific activity-based probes and activity profiling. Selective inhibitors were applied to dissect the roles of the individual peptidases and determine the peptidase-specific cleavage map of the hemoglobin molecule. Because of their central function in nutrition of the parasite, the identified enzymes are potential targets to developing novel anti-tick vaccines that limit parasite survival and disease transmission.
    Permanent Link: http://hdl.handle.net/11104/0178196

     
     
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