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Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model.

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    0333037 - ÚEM 2010 RIV US eng J - Journal Article
    Rodríguez Arellano, Jose Julio - Jones, V. C. - Verkhratsky, Alexei
    Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model.
    [Proliferace poškozených buněk v subventrikulární zóně u modelu Alzheimerovy choroby.]
    Neuroreport. Roč. 20, č. 10 (2009), s. 907-912. ISSN 0959-4965. E-ISSN 1473-558X
    R&D Projects: GA ČR GA309/09/1696
    Institutional research plan: CEZ:AV0Z50390512
    Keywords : adult neurogenesis * Alzheimer's disease * cell proliferation
    Subject RIV: FH - Neurology
    Impact factor: 1.805, year: 2009

    In mammalian central nervous system, neurogenesis occurs in the hippocampus and the subventricular zone (SVZ). Our results indicate that 3 x Tg-AD mice have impaired SVZ cell proliferation, which exacerbates with age.

    V CNS savců se neurogeneze vyskytuje v hipokampu a v subventrikulární zóně (SVZ). Naše výsledky prokázaly, že v SVZ transgenních zvířat s modelem Alzheimerovy choroby (3xTg-AD) je narušena proliferace buněk, která se s věkem ještě prohlubuje.
    Permanent Link: http://hdl.handle.net/11104/0178122

     
     
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