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Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
- 1.0333023 - ÚOCHB 2010 RIV GB eng J - Journal Article
Hlouchová, Klára - Bařinka, C. - Konvalinka, Jan - Lubkowski, J.
Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.
FEBS Journal. Roč. 276, č. 16 (2009), s. 4448-4462. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : GCPIII * NAALADase II * metallopeptidase
Subject RIV: CE - Biochemistry
Impact factor: 3.042, year: 2009
The study reports of several functional complexes of recombinant human GCPIII that allow for a direct comparison with equivalent GCPII complexes. That reveals differences in the organization of specificity pockets, in surface charge distribution, and in the occupancy of the co-catalytic zinc sites. The data presented here provide information that should prove to be essential for the structurally- aided design of GCPIII-specific ligands.
Permanent Link: http://hdl.handle.net/11104/0178112
Number of the records: 1