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Norbornane as the novel pseudoglycone moiety in nucleosides
- 1.0331982 - ÚOCHB 2010 RIV GB eng J - Journal Article
Šála, Michal - Hřebabecký, Hubert - Dračínský, Martin - Masojídková, Milena - De Palma, A. - Neyts, J. - Holý, Antonín
Norbornane as the novel pseudoglycone moiety in nucleosides.
Tetrahedron. Roč. 65, č. 45 (2009), s. 9291-9299. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : carbocyclic nucleosides * norbornane * coxsackie virus
Subject RIV: CC - Organic Chemistry
Impact factor: 3.219, year: 2009
This study concerns synthesis of novel racemic conformationally locked nucleosides with bicyclo[2.2.1]heptene or heptane ring system substituted with nucleobase at position 7 and with the anti-configuration of the nucleobase. Biological activity of the newly prepared compounds is described. Activity against Coxsackie B3 virus is discussed.
Permanent Link: http://hdl.handle.net/11104/0177350
Number of the records: 1