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Replication of Restless Legs Syndrome Loci in Three European Populations
- 1.0331384 - ÚEM 2010 RIV GB eng J - Journal Article
Kemlink, D. - Polo, O. - Frauscher, B. - Gschliesser, V. - Högl, B. - Poewe, W. - Vodička, Pavel - Vávrová, J. - Šonka, K. - Nevšímalová, S. - Schormair, B. - Lichtner, P. - Silander, K. - Peltonen, L. - Gieger, C. - Wichmann, H. E. - Zimprich, A. - Roeske, D. - Müller-Myhsok, B. - Meitinger, T. - Winkelmann, J.
Replication of Restless Legs Syndrome Loci in Three European Populations.
Journal of Medical Genetics. Roč. 46, č. 5 (2009), s. 315-318. ISSN 0022-2593. E-ISSN 1468-6244
R&D Projects: GA MZd NR8563
Grant - others:GA MŠk(CZ) MSM0021620816
Institutional research plan: CEZ:AV0Z50390512
Keywords : periodic limb movements * genetic risk-factor * susceptibility locus
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.751, year: 2009
Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. Our study shows that variants in these three loci confer consistent disease risks in patients of European descent. Among the known loci, BTBD9 seems to be the most consistent in its effect on RLS across populations and is also most independent of familial clustering.
Permanent Link: http://hdl.handle.net/11104/0176913
Number of the records: 1