Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats

0330845 - ÚOCHB 2010 RIV CH eng J - Journal Article
Stofková, A. - Haluzík, M. - Železná, Blanka - Kiss, A. - Skurlová, M. - Lacinová, Z. - Jurcovicová, J.
Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats.
Neuroimmunomodulation. Roč. 16, č. 6 (2009), s. 377-384. ISSN 1021-7401. E-ISSN 1423-0216
R&D Projects: GA ČR GA305/06/0427
Institutional research plan: CEZ:AV0Z40550506
Keywords : adjuvant arthritis * anorexia * leptin * adiponectin
Subject RIV: CC - Organic Chemistry
Impact factor: 2.034, year: 2009

Food intake is activated by hypothalamic orexigenic neuropeptide Y (NPY) controlled by leptin and ghrelin. Rat adjuvant arthritis (AA), and also human rheumatoid arthritis, is associated with cachexia. In our study, we evaluated NPY expression in hypothalamic arcuate nucleus (nARC) under AA-induced changes in leptin, ghrelin and adiponectin. Anorexia is centrally induced by IL-1β whose expression in the nARC was studied as well. In AA rats, decreased appetite, body mass, and epididymal fat positively correlated with reduced circulating and epididymal fat leptin and adiponectin. Plasma ghrelin was increased. In nARC, mRNA for leptin and ghrelin receptors, NPY, and IL-1beta were over-expressed in AA rats. However, circulating and spleen IL-1beta was unaltered in AA rats. During AA, despite of over-expression of orexigenic NPY in nARC, activated expression of IL-1beta in nARC kept AA-induced anorexia in progress. Lowered adiponectin might contribute to this anorexia.
Permanent Link: http://hdl.handle.net/11104/0176533