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Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

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    0330753 - ÚOCHB 2010 RIV US eng J - Journal Article
    Grantz Šašková, Klára - Kožíšek, Milan - Řezáčová, Pavlína - Brynda, Jiří - Yashina, T. - Kagan, R. M. - Konvalinka, Jan
    Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir.
    Journal of Virology. Roč. 83, č. 17 (2009), s. 8810-8818. ISSN 0022-538X. E-ISSN 1098-5514
    R&D Projects: GA MŠMT 1M0508
    EU Projects: European Commission(XE) 37693 - HIV PI RESISTANCE
    Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
    Keywords : HIV-1 protease * darunavir * X-ray structural analysis * protease inhibitor * mutations
    Subject RIV: CE - Biochemistry
    Impact factor: 5.150, year: 2009

    In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens.
    Permanent Link: http://hdl.handle.net/11104/0176467

     
     
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