Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats

0330737 - FGÚ 2010 RIV GB eng J - Journal Article
Šimko, F. - Pecháňová, Olga - Pelouch, Václav - Krajčírovičová, K. - Müllerová, M. - Bednárová, K. - Adamcová, M. - Paulis, L.
Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats.
[Vliv melatoninu, captoprilu, spironolaktonu a simvastatinu na krevní tlak a remodelaci levé komory srdeční u spontánně hypertenzních potkanů.]
Journal of Hypertension. Roč. 27, Suppl.6 (2009), S5-S10. ISSN 0263-6352. E-ISSN 1473-5598
R&D Projects: GA ČR GA305/09/0336
Institutional research plan: CEZ:AV0Z50110509
Keywords : cardiac hypertrophy * fibrosis * ventricular remodeling
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 4.988, year: 2009

Melatonin was shown to reduce blood pressure and oxidative load as well as to increase nitric oxide availability. It was investigated whether melatonin can reverse left ventricular remodeling in spontaneously hypertensive rats and to compare its protective effect with captopril, spironolactone, or simvastatin. It is concluded that although melatonin, in comparison with captopril, did not reverse left ventricle hypertrophy, it reversed left ventricular fibrosis due to its prominent antioxidative effect

Melatonin snižuje krevní tlak a oxidační stres, zatímco zvyšuje dostupnost NO. Bylo zkoumáno, zda může melatonin odstranit již vyvinutou remodelaci levé komory srdeční u spontánně hypertenzních potkanů a jeho činky byly porovnávány s captoprilem, spironolaktonem a simvastatinem. Ačkoliv melatonin (na rozdíl od captoprilu) neodstraní vyvinutou hypertrofii levé komory, zmírní stupeň fibrózy díky svému antioxidačnímu působení
Permanent Link: http://hdl.handle.net/11104/0176452