Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension

0330723 - FGÚ 2010 RIV GB eng J - Journal Article
Vranková, S. - Jendeková, L. - Paulis, L. - Sládková, M. - Šimko, F. - Pecháňová, Olga
Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension.
[Srovnání účinků indapamidu a captoprilu na vývoj spontánní hypertenze.]
Journal of Hypertension. Roč. 27, Suppl.6 (2009), S42-S46. ISSN 0263-6352. E-ISSN 1473-5598
R&D Projects: GA ČR GA305/09/0336
Institutional research plan: CEZ:AV0Z50110509
Keywords : cardiac hypertrophy * nitric oxide * oxidant status
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 4.988, year: 2009

The effects of indapamide, a thiazide-like diuretic, and captopril, an angiotensin-converting enzyme inhibitor, on spontaneous hypertension and the development of left ventricular hypertrophy (LVH), nitric oxide generation and oxidant status were investigated. Whereas captopril reduced LVH, indapamide enhanced NOS activity and decreased oxidative damage in the case of the combined treatment. The complex protective effects of the combined indapamide plus captopril treatment on hypertension are exerted via its effects on blood pressure, heart hypertrophy and vasorelaxation

Byly studovány účinky diuretika indapamidu a inhibitoru konvertujícího enzymu captoprilu na vývoj spontánní hypertenze, hypertrofii srdeční, tvorbu NO a oxidační status. Captopril zmenšoval srdeční hypertrofii, zatímco indapamid zlepšoval tvorbu NO a snižoval oxidační poškození. Komplexní protektivní působení kombinace indapamidu a captoprilu je zprostředkováno účinky na krevní tlak, srdeční hypertrofii a vasorelaxaci
Permanent Link: http://hdl.handle.net/11104/0176440