Resveratrol attenuates lipopolysaccharide-induced hepatitis in D-Galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1

0330496 - ÚEM 2010 RIV NL eng J - Journal Article
Farghali, H. - Černý, D. - Kameníková, L. - Martínek, J. - Hořínek, A. - Kmoníčková, Eva - Zídek, Zdeněk
Resveratrol attenuates lipopolysaccharide-induced hepatitis in D-Galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1.
Nitric Oxide-Biology and Chemistry. Roč. 21, 3-4 (2009), s. 216-225. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA ČR GA305/07/0061
Grant - others:GA ČR(CZ) GA305/09/0004; GA MZd(CZ) NR9379
Institutional research plan: CEZ:AV0Z50390512
Keywords : resveratrol * lipopolysacchride * nitrix oxide
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 2.506, year: 2009

Resveratrol improves hepatotoxic markers and morphology after the hepatic insult. Among the mechanisms responsible for the hepatoprotective effects of resveratrol are reduction of NO production, downeregulation of nitric oxide synthese, madification of oxidative stress parameters and modulation of heme oxygenase-1.
Permanent Link: http://hdl.handle.net/11104/0176277