Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice

0330364 - ÚJF 2010 RIV US eng J - Journal Article
Bäurle, J. - Kučera, Jan - Frischmuth, S. - Lambertz, M. - Kranda, Karel
Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice.
Brain Pathology. Roč. 19, č. 4 (2009), s. 586-595. ISSN 1015-6305. E-ISSN 1750-3639
R&D Projects: GA ČR GA309/09/1189
Institutional research plan: CEZ:AV0Z10480505
Keywords : apoptosis * copper * excitotoxicity
Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders
Impact factor: 5.903, year: 2009

Elevated concentrations of Zn, Cu and Fe, observed in biopsied or post-mortem tissue from diseased human brains, have often been considered as some of the major factors in the etiology of excitotoxic neuronal death but without any direct evidence for the causal role of metals. Although elevated metal concentrations that precede or coincide with the onset of neurodegeneration may provide such evidence, the dynamics of metal concentrations during excitotoxic cell death has never been established. Hence, we measured time-resolved Zn, Cu and Fe concentrations during the course of excitotoxic cell death in the Lurcher (Lc/+) mutant mouse with neutron activation analysis.
Permanent Link: http://hdl.handle.net/11104/0176171