Mathematical Modeling of Chondrocyte Proliferation on Nanofibrous Scaffolds. Theoretical Analysis and Experiments

0329509 - ÚT 2010 RIV PT eng C - Conference Paper (international conference)
Maršík, František - Filová, Eva - Kozák, J. - Klika, Václav - Martinová, L. - Lukáš, D. - Michálek, Jiří - Přádný, Martin - Amler, Evžen
Mathematical Modeling of Chondrocyte Proliferation on Nanofibrous Scaffolds. Theoretical Analysis and Experiments.
ICTE 2009 International Conference on Tissue Engineering an Eccomas Thematic Conference. Leiria: Polytechnic Institute of Leiria, 2009 - (Bártolo, P.; Fernandes, P.; Ruben, R.; Folgado, J.; Almeida, H.; Alves, N.; Mendes, A.), s. 123-130. ISBN 978-972-8469-90-0.
[ICTE 2009 International Conference on Tissue Engineering an Eccomas Thematic Conference. Leiria (PT), 09.07.2009-11.07.2009]
R&D Projects: GA AV ČR IAA500390702; GA MŠMT 2B06130; GA ČR(CZ) GA106/08/0557
Institutional research plan: CEZ:AV0Z20760514; CEZ:AV0Z50390703; CEZ:AV0Z40500505
Keywords : tissue Engineering * scaffold * biomaterials
Subject RIV: FI - Traumatology, Orthopedics

Chondrocytes (CH) differentiation and proliferation on various scaffolds in vitro was studied theoretically and also experimentally. Theoretical analysis was based on the interaction of the cells with both medium components (MC) including foetal bovine serum (FBS) and growth factors, and the nanofibrous poly(lactic-co-glycolic acid) (PLGA) and poly(2-ethoxyethyl methacrylate) (PEOEMA) scaffolds or tissue culture polystyrene (TCP). The multiplication of activated chondrocytes (CHA), the synthesis of both collagen (COL) and glycosaminoglycans (GAG) on the scaffold (SC), and MC consumption were formulated on the base of chemical kinetic equations, which are set up on the experimental observations.
Permanent Link: http://hdl.handle.net/11104/0175521