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Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11beta-hydroxysteroid dehydrogenase type 2 in the rat placenta
- 1.0329480 - FGÚ 2010 RIV US eng J - Journal Article
Vacková, Z. - Vagnerová, Karla - Libra, A. - Mikšík, Ivan - Pácha, Jiří - Staud, F.
Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11beta-hydroxysteroid dehydrogenase type 2 in the rat placenta.
[Podávání dexametasonu a betametasonu během těhotenství ovlivňuje expresi a funkci 11beta-hydroxysteroiddehydrogenasy v placentě potkana.]
Reproductive Toxicology. Roč. 28, č. 1 (2009), s. 46-51. ISSN 0890-6238. E-ISSN 1873-1708
R&D Projects: GA AV ČR(CZ) KJB5011402
Grant - others:Univerzita Karlova(CZ) 102/2006/C/FaF
Institutional research plan: CEZ:AV0Z50110509
Keywords : placenta * syntetic glucocorticoids * 11-betahydroxysteroid dehydrogenasa
Subject RIV: ED - Physiology
Impact factor: 3.367, year: 2009
Placental barrier function mediated by 11-betahydroxysteroid dehydrogenase type 2, an enzyme that protects the fetus against abundance of maternal glucocorticoids, might be considerably impaired by the antenatal therapy with dexamethasone and betamethasone
Enzym 11beta-hydroxysteroiddehydrogenasa typu 2 zabezpečuje funkci placenty jako bariery chránící plod před nadbytkem maternálních glukokortikoidů. Podávání dexametasonu nebo betametasonu během těhotenství může výrazně zhoršit tuto barierovou funkci
Permanent Link: http://hdl.handle.net/11104/0175504
Number of the records: 1