Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period

0328977 - FGÚ 2010 RIV US eng J - Journal Article
Walton, K. M. - Fisher, K. - Rubitski, D. - Marconi, M. - Meng, Q.-J. - Sládek, Martin - Adams, J. - Bass, M. - Chandrasekaran, R. - Butler, T. - Griffor, M. - Rajamohan, F. - Serpa, M. - Chen, Y. - Claffey, M. - Hastings, M. - Loudon, A. - Maywood, E. - Ohren, J. - Doran, A. - Wager, T. T.
Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period.
Journal of Pharmacology and Experimental Therapeutics. Roč. 330, č. 2 (2009), s. 430-439. ISSN 0022-3565. E-ISSN 1521-0103
Institutional research plan: CEZ:AV0Z50110509
Keywords : circadian clock * casein kinase 1 epsilon * inhibitor
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.093, year: 2009

Casein kinases 1 (CK1) epsilon and delta mutations have dramatic effect on circadian clock period. We have previously shown, that pan-CK1delta/epsilon inhibitor causes a delay in animal models of circadian rhythm, however it remains unclear, whether one of the kinases has predominant role. Here we have used novel selective CK1 epsilon inhibitor to show that wild-type CK1 epsilonhas only minimal effect on circadian clock relative to CK1 delta
Permanent Link: http://hdl.handle.net/11104/0175143