Changes of parvalbumin expression in the spinal cord after peripheral inflammation

0328959 - FGÚ 2010 RIV CZ eng J - Journal Article
Zachařová, Gisela - Sojka, David - Paleček, Jiří
Changes of parvalbumin expression in the spinal cord after peripheral inflammation.
Physiological Research. Roč. 58, č. 3 (2009), s. 435-442. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA305/06/1115; GA ČR(CZ) GA304/08/0256; GA MŠMT(CZ) LC554
Grant - others:EC(XE) LSH-CT-2004-511978
Institutional research plan: CEZ:AV0Z50110509
Keywords : pain * parvalbumin * spinal cord * GABA
Subject RIV: FH - Neurology
Impact factor: 1.430, year: 2009

Parvalbumin (PV) is a calcium-binding protein that is expressed by numerous neuronal subpopulations in the central nervous system.There was a significant reduction of PV immunoreactivity in the superficial dorsal horn region ipsilateral to the arthritis after induction of the peripheral inflammation. The ipsilateral area and intensity of PV staining in this area were reduced to 38 % and 37 %, respectively, out of the total PV staining on both sides. It is suggested that this reduction may reflect decreased expression of PV in GABAergic inhibitory neurons. Reduction of PV concentration in the presynaptic GABAergic terminals could lead to potentiation of inhibitory transmission in the spinal cord. Our results suggest that changes in expression of calcium-binding proteins in spinal cord dorsal horn neurons may modulate nociceptive transmission
Permanent Link: http://hdl.handle.net/11104/0175129