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Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom
- 1.0328907 - ÚOCHB 2010 RIV DE eng J - Journal Article
Dračínský, Martin - Holý, Antonín - Jansa, Petr - Kovačková, Soňa - Buděšínský, Miloš
Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom.
European Journal of Organic Chemistry. -, č. 24 (2009), s. 4117-4122. ISSN 1434-193X. E-ISSN 1099-0690
R&D Projects: GA AV ČR KJB400550903
Institutional research plan: CEZ:AV0Z40550506
Keywords : isotopes * NMR spectroscopy * pyrimidines
Subject RIV: CC - Organic Chemistry
Impact factor: 3.096, year: 2009
Anotace angl: The proton to deuterium exchange reaction of hydrogen atom in position 5 of the fifteen pyrimidine derivatives was studied. The exchange proceeds under both acidic and alkaline conditions: under acidic conditions, the mechanism involves protonation at position 5 (forming a s-complex), whereas under alkaline conditions, the exchange is caused mainly by the equilibrium of the tautomers involving one tautomer with a sp3 -hybridised carbon atom in position 5.
Permanent Link: http://hdl.handle.net/11104/0175095
Number of the records: 1