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Tetrathiafulvalene-labelled nucleosides and nucleoside triphosphates. Synthesis, electrochemistry and scope of their polymerase incorporation into DNA

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    0328740 - ÚOCHB 2010 RIV DE eng J - Journal Article
    Riedl, Jan - Horáková Brázdilová, Petra - Šebest, Peter - Pohl, Radek - Havran, Luděk - Fojta, Miroslav - Hocek, Michal
    Tetrathiafulvalene-labelled nucleosides and nucleoside triphosphates. Synthesis, electrochemistry and scope of their polymerase incorporation into DNA.
    European Journal of Organic Chemistry. -, č. 21 (2009), s. 3519-3525. ISSN 1434-193X. E-ISSN 1099-0690
    R&D Projects: GA AV ČR(CZ) IAA400040901
    Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50040507
    Keywords : nucleoside triphosphates * DNA polymerase * tetrathiafulvalene
    Subject RIV: CC - Organic Chemistry
    Impact factor: 3.096, year: 2009

    DNA labeling by tetrathiafulvalene was attempted. TTF-modified nucleoside triphosphates were prepared and tested as substrates for DNA polymerases. Their enzymatic incorporation was inefficient and at higher concentration they fully inhibited the polymerase.
    Permanent Link: http://hdl.handle.net/11104/0174977

     
     
Number of the records: 1  

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