Oligopyridine-ruthenium(II)-amino acid conjugates: synthesis, characterization, DNA binding properties and interactions with the oligonucleotide duplex d(5'-CGCGCG-3')2

0328691 - BFÚ 2010 RIV GB eng J - Journal Article
Triantafillidi, K. - Karidi, K. - Malina, Jaroslav - Garoufis, A.
Oligopyridine-ruthenium(II)-amino acid conjugates: synthesis, characterization, DNA binding properties and interactions with the oligonucleotide duplex d(5'-CGCGCG-3')2.
[Konjugáty oligopyridin-ruthenium(ii)-aminokyselina: syntéza, charakterizace, vazba na DNA a interakce s oligonukleotidem d(5'-CGCGCG-3')2.]
Dalton Transactions. -, č. 32 (2009), s. 6403-6415. ISSN 1477-9226. E-ISSN 1477-9234
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : oligopyridine-ruthenium(II)-amino acid conjugates * diastereomeric DNA binding * DNA photocleavage
Subject RIV: BO - Biophysics
Impact factor: 4.081, year: 2009

Diastereomeric oligopyridine-ruthenium(II)-amino acid conjugated complexes of the general formulas lambda- and delta-[Ru(bpy)2(4,4'(CO2Y)2-bpy)]2+, where Y = L-AlaCONH2, L-LysCONH2, L-HisCONH2, L-TyrCONH2, were synthesized and characterized. Their binding properties with ct-DNA and the oligonucleotide duplex d(5'-CGCGCG-3')2, were studied.

Byly syntetizovány a charakterizovány konjugáty oligopyridin-ruthenium(II)-aminokyselina s obecným vzorcem lambda a delta-[Ru(bpy)2(4,4'(CO2Y)2-bpy)]2+, kde Y = L-AlaCONH2, L-LysCONH2, L-HisCONH2, L-TyrCONH2 a byla studována jejich interakce s DNA a oligonukleotidem d(5'-CGCGCG-3')2.
Permanent Link: http://hdl.handle.net/11104/0174943