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Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells
- 1.0328368 - MBÚ 2010 RIV US eng J - Journal Article
Kuželová, K. - Grebeňová, D. - Pluskalová, M. - Kavan, Daniel - Halada, Petr - Hrkal, Z.
Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells.
Journal of Cellular Biochemistry. Roč. 106, č. 4 (2009), s. 673-681. ISSN 0730-2312. E-ISSN 1097-4644
R&D Projects: GA MZd NR9243
Institutional research plan: CEZ:AV0Z50200510
Keywords : k562 * apoptosis * 14-3-3
Subject RIV: CE - Biochemistry
Impact factor: 2.935, year: 2009
The proteins of 14-3-3 family are substantially involved in the regulation of many biological processes including the apoptosis. We studied the changes in the expression of five 14-3-3 isoforms during the apoptosis of JURL-MK1 and K562 cells. The expression level of all these proteins markedly decreased in relation with the apoptosis progression and all isoforms underwent truncation, which probably corresponds to the removal of several C-terminal amino acids. The observed 14-3-3 modifications were partially blocked by caspase-3 inhibition
Permanent Link: http://hdl.handle.net/11104/0174698
Number of the records: 1