Labelled compounds as radiopharmaceuticals for radiosynoviorthesis

0328173 - ÚJF 2010 RIV HU eng J - Journal Article
Melichar, František - Kropáček, Martin - Šrank, Jiří - Beran, Miloš - Mirzajevová, Marcela - Zimová, Jana - Eigner-Henke, Kateřina - Forsterová, Michaela
Labelled compounds as radiopharmaceuticals for radiosynoviorthesis.
Journal of Radioanalytical and Nuclear Chemistry. Roč. 280, č. 2 (2009), s. 353-358. ISSN 0236-5731. E-ISSN 1588-2780.
[2nd International Nuclear Chemistry Congress (2nd-INCC). Cancun, 13.04.2008-17.04.2008]
R&D Projects: GA MŠMT OE08018; GA MPO 2A-1TP1/055; GA MŠMT 2B06165
Institutional research plan: CEZ:AV0Z10480505
Keywords : RHEUMATOID-ARTHRITIS * RADIATION SYNOVECTOMY * FOLLOW-UP
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 0.631, year: 2009

Radiopharmaceuticals for radiosynoviorthesis are designed as suspension (colloidal) of particles in sterile and pyrogen free form, where radionuclide (active substance) fix on carrier which is form solid particles or gel form. Generally, radionuclide and carrier have to fulfil the request of sterility, chemical purity, non toxicity, non allergen and low cost preparation. In term of the radionuclide purity, beta-emission with sufficient energy for penetration and ablation the synovial tissue and low gamma-radiation is requested. The radionuclide gold-198 in colloidal form was used as radiopharmaceutical for radiosynoviorthesis at first. Presently, beta-emitting radionuclides, which have no or only a minimal gammaemission, are used.
Permanent Link: http://hdl.handle.net/11104/0005419