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Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats

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    0327874 - FGÚ 2010 RIV NL eng J - Journal Article
    Folbergrová, Jaroslava - Druga, Rastislav - Tsenov, Grygoriy - Haugvicová, Renata - Otáhal, Jakub
    Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats.
    Brain Research. Roč. 1273, - (2009), s. 144-154. ISSN 0006-8993. E-ISSN 1872-6240
    R&D Projects: GA ČR(CZ) GA309/05/2015; GA ČR GA309/08/0292; GA ČR(CZ) GA304/07/1137
    Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z50200510
    Keywords : DL-homocysteic acid-induced seizures * posttreatment with 2R * 4R-APDC * partial protection
    Subject RIV: FH - Neurology
    Impact factor: 2.463, year: 2009

    Anticonvulsant and neuroprotective effect of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate, agonist for group II metabotropic glutamate receptors, was substantially reduced when given after the onset of seizures induced in immature rats by homocysteic acid. The severity of seizures, changes of brain energy metabolites and neuronal damage of hippocampus and thalamus were influenced only partially
    Permanent Link: http://hdl.handle.net/11104/0174325

     
     
Number of the records: 1  

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