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Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide)
- 1.0327533 - ÚMCH 2010 RIV US eng J - Journal Article
Matějíček, P. - Zedník, J. - Ušelová, K. - Pleštil, Josef - Fanfrlík, Jindřich - Nykanen, A. - Ruokolainen, J. - Hobza, Pavel - Procházka, K.
Stimuli-responsive nanoparticles based on interaction of metallacarborane with poly(ethylene oxide).
Macromolecules. Roč. 42, č. 13 (2009), s. 4829-4837. ISSN 0024-9297. E-ISSN 1520-5835
R&D Projects: GA ČR(CZ) GD203/05/H001; GA AV ČR 1ET400500402; GA AV ČR IAAX00320901
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z40550506
Keywords : block-copolymer micelles * light-scattering * dicarbollide anions
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.539, year: 2009
The antiviral active boron cluster [3-cobalt bis(1,2-dicarbollide)](-1) anion, CoD, interacts and forms a stable complex with one of the most widely used polymeric component of drug delivery systems: poly(ethylene oxide), PEO. The formation of insoluble NaCoD/PEO complex can be exploited in design of water-soluble metallacarborane-containing nanoparticles that could offer applications in medicine. We studied the boron cluster interaction with a hydrophilic block copolymer: poly(ethylene oxide)-block-poly(methacrylic acid), PEO-PMA. The interaction leads to a spontaneous formation of core-shell nanoparticles. The insoluble core contains the PEO/CoD complex, while the polyanionic PMA blocks, which do not interact with the metallacarborane, form the pH-responsive micellar shell and stabilize the particles in aqueous media.
Permanent Link: http://hdl.handle.net/11104/0005384
Number of the records: 1