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Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension
- 1.0327402 - FGÚ 2010 RIV PL eng J - Journal Article
Pecháňová, Olga - Jendeková, L. - Vranková, S.
Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension.
[Efekt chronického podávání apocyninu na oxid dusnatý a kyslíkové radikály u hraniční a spontánní hypertenze.]
Pharmacological Reports. Roč. 61, č. 1 (2009), s. 116-122. ISSN 1734-1140. E-ISSN 2299-5684
Grant - others:VEGA(SK) 2/0178/09; APVV(SK) 0538-07; VEGA(SK) 1/0142/09; APVT(SK) 51-017902; APVV(SK) 0586-06
Institutional research plan: CEZ:AV0Z50110509
Keywords : NO synthase * rective oxygen species * apocynin
Subject RIV: ED - Physiology
Impact factor: 2.086, year: 2009
The purpose of the study was to investigate the effect of NADPH oxidase inhibitor – apocynin - on blood pressure rise in borderline and spontaneously hypertensive rats. This treatment partially prevented blood pressure rise in both models, but it has no influence on nitric oxide synthase activity. However, apocynin decreased production of reactive oxygen species and thus prevented a decrease in cGMP formation
Cílem studie bylo zkoumat vliv inhibitoru NADP oxidázy – apocyninu – na vzestup krevního tlaku u potkanů s hraniční nebo spontánní hypertenzí. Tato terapie částečně omezuje vzestup tlaku u obou modelů, je bez vlivu na produkci oxidu dusnatého, ale snižuje tvorbu kyslíkových radikálů a tím zabraňuje poklesu hladin cGMP
Permanent Link: http://hdl.handle.net/11104/0174230
Number of the records: 1