- Hydroxylated Anthraquinones Produced by Geosmithia species

0327075 - MBÚ 2010 RIV CZ eng J - Journal Article
Stodůlková, Eva - Kolařík, Miroslav - Křesinová, Zdena - Kuzma, Marek - Šulc, Miroslav - Man, Petr - Novák, Petr - Maršík, Petr - Landa, Přemysl - Olšovská, Jana - Chudíčková, Milada - Pažoutová, Sylvie - Černý, J. - Bella, J. - Flieger, Miroslav
- Hydroxylated Anthraquinones Produced by Geosmithia species.
Folia Microbiologica. Roč. 54, č. 3 (2009), s. 179-187. ISSN 0015-5632. E-ISSN 1874-9356
R&D Projects: GA AV ČR KAN200200651; GA MŠMT LC07017; GA MŠMT 1M0506; GA ČR GP203/05/P575
Grant - others:CZ(CZ) 205/2004
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z50380511
Keywords : hydroxylated anthraquinones * staphylococcus aureus * mammalian cell lines
Subject RIV: EE - Microbiology, Virology
Impact factor: 0.978, year: 2009

Hydroxylated anthraquinones (yellow, orange, and red pigments), were found to be the most abundant compounds produced into the medium during the submerged cultivation. Three main compounds were identified as 1,3,6,8-tetrahydroxyanthraquinone (1), rhodolamprometrin (1-acetyl-2,4,5,7-tetrahydroxyanthraquinone; 2), and 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone (3). Compounds 2 and 3 (representing the majority of produced metabolites) inhibited the growth of G plus minus bacteria Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration of 64–512 g/mL. Anti-inflammatory activity detected as inhibition of cyclooxygenase-2 was found only for compound 3 at 1 and 10 g/mL. Compound 2 interfered with the morphology, compound 3 with cell-cycle dynamics of adherent mammalian cell lines
Permanent Link: http://hdl.handle.net/11104/0173976