Knockdown of proteins involved in iron metabolism limits tick reproduction and development

0327046 - BC 2010 RIV US eng J - Journal Article
Hajdušek, O. - Sojka, Daniel - Kopáček, Petr - Burešová, Veronika - Franta, Zdeněk - Šauman, Ivo - Winzerling, J. - Grubhoffer, L.
Knockdown of proteins involved in iron metabolism limits tick reproduction and development.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 106, č. 4 (2009), s. 1033-1038. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA MŠMT(CZ) LC06009; GA MŠMT LC07032; GA AV ČR IAA600220603
Institutional research plan: CEZ:AV0Z60220518; CEZ:AV0Z50070508
Keywords : tick ferritin * iron metabolism * RNA interference
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 9.432, year: 2009

We have characterized a new secreted ferritin (Fer2) and an iron regulatory protein (IRP1) from the hard tick, Ixodes ricinus, and have demonstrated their relationship to a previously described tick intracellular ferritin (Fer1). Using RNA interference, we have proved that Fer2 plays a role as a transporter of non-heme iron from the tick gut to the periheral tissues. Knockdown of Fer2 dramatically impairs the ability of ticks to feed, thus making Fer2 a promising candidate for development of an efficient anti-tick vaccine.
Permanent Link: http://hdl.handle.net/11104/0173951