Conformational evaluation of labeled C3'-O-P-13CH2-O-C4'' phosphonate internucleotide linkage, a phosphodiester isostere

0326865 - ÚOCHB 2010 RIV US eng J - Journal Article
Točík, Zdeněk - Buděšínský, Miloš - Barvík Jr., I. - Rosenberg, Ivan
Conformational evaluation of labeled C3'-O-P-13CH2-O-C4'' phosphonate internucleotide linkage, a phosphodiester isostere.
Biopolymers. Roč. 91, č. 7 (2009), s. 514-529. ISSN 0006-3525. E-ISSN 1097-0282
R&D Projects: GA AV ČR KAN200520801; GA MŠMT(CZ) LC06061; GA MŠMT(CZ) LC06077
Institutional research plan: CEZ:AV0Z40550506
Keywords : nucleoside phosphonate * 13C labeling * NMR
Subject RIV: CC - Organic Chemistry
Impact factor: 2.605, year: 2009

Study of 13C-labeled, C3'-O-P-13CH2-O-C4'' phosphonate internucleotide linkage in model thymidine dimer by means of NMR spectroscopy, MD simulations and ab initio calculations provided a thorough stereochemical evaluation of the linkage which is an isosteric alternative to the natural phosphodiester bond.
Permanent Link: http://hdl.handle.net/11104/0173829